Therapeutics

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties

• ECM stiffness and deposition fuel vocal fold cancer progression through mechanotransduction. • Patient-derived cells show loss of laminin-binding integrins and flocking motility

PTC Therapeutics Ends Bid to Seek FDA Approval for Rare Muscle Disease Drug

• PTC Therapeutics said it cannot resolve differences it has with the FDA in interpreting clinical trial data for Translarna, a drug it developed for Duchenne muscular dystrophy. •