Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

• Abstract Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. • Here we assessed an individualized neoantigen mRNA vacc

Science · February 20, 2026 (updated February 24, 2026) · 2 min · 282 words
Nucleotide signals coordinate activation and inhibition of bacterial immunity

Nucleotide signals coordinate activation and inhibition of bacterial immunity

• Abstract The cellular nucleotide pool is a major focal point of the host immune response to viral infection. • Immune effector proteins that disrupt the nucleotide pool enable an

Science · February 19, 2026 (updated February 24, 2026) · 1 min · 181 words
Highly dynamic dural sinuses support meningeal immunity

Highly dynamic dural sinuses support meningeal immunity

• Abstract The central nervous system is surrounded by three interconnected membranes referred to as the meninges, which host a diverse immune network1,2,3. • Within the skull-inte

Science · February 19, 2026 (updated February 24, 2026) · 1 min · 142 words