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    <title>Gpcr on Tenu Tech Brief</title>
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      <title>OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours</title>
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      <pubDate>Wed, 25 Feb 2026 17:32:59 +0000</pubDate>
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      <description>• Abstract Chimeric antigen receptor (CAR)-natural killer (NK) cell therapies hold promise for solid tumours but remain limited because of poor tumour infiltration, persistence and</description>
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      <title>De novo design of GPCR exoframe modulators</title>
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      <pubDate>Wed, 18 Feb 2026 00:39:57 +0000</pubDate>
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      <description>• Abstract G-protein-coupled receptors (GPCRs) are important therapeutic targets and have been targeted mainly through their orthosteric site, where the endogenous agonist binds1.</description>
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