• This reengineered HPV vaccine trains T cells to hunt down cancer A tiny structural tweak transformed an HPV cancer vaccine into a far more potent tumor fighter. • Over the last decade, scientists at Northwestern University have identified a key insight about how vaccines work. • The ingredients matter, but the way those ingredients are physically arranged can dramatically influence performance. • After validating this concept in multiple studies, the researchers applied it to therapeutic cancer vaccines aimed at HPV-driven tumors. • In their latest work, they found that simply adjusting the orientation and position of a single cancer targeting peptide significantly strengthened the immune system’s ability to attack tumors. • The study was published Feb.
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