• Researchers from Tokyo Metropolitan University have created a new molecule which carries DNA into biological cells, to treat or vaccinate against illnesses. • Many existing options rely on molecules with a strong positive charge, which can cause harmful inflammation. • The team overcame this by using a neutral molecule and a new method to bind DNA to it, making it possible to deliver DNA into cells. • Successful experiments in mice promise new, more effective therapies. • The findings are published in the journal ACS Applied Bio Materials.
Article Summaries:
- Tokyo Metropolitan University scientists have engineered a neutral‑charged molecule that can bind and deliver DNA into biological cells, offering a potential alternative to the positively charged carriers that often trigger inflammation. By developing a new binding method, the team demonstrated efficient DNA uptake in mouse models, suggesting the platform could support future therapies and vaccines. The results, published in ACS Applied Bio Materials, highlight the molecule’s promise for safer gene‑delivery applications, though further studies are needed to confirm efficacy and safety in humans.
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