• Single dose of DMT produced rapid, sustained reduction in depressive symptoms among treatment-resistant patients. • Trial included 34 participants with moderate‑to‑severe depression, each failed at least two conventional therapies. • Half received 21.5‑mg intravenous DMT over 10 minutes; the rest received placebo. • DMT group’s depression scores dropped 7.4 points more than placebo after two weeks. • Improvement persisted for three months, with some participants maintaining benefits up to six months. • Findings support psychedelics as promising therapy for depression unresponsive to standard treatments.
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