• Email Bluesky Facebook LinkedIn Reddit Whatsapp X An enzyme produced by liver cells (pictured) has anti-ageing effects on the brain • Credit: Biophoto Associates/Science Photo Library Exercise prevents brain ageing and memory loss by strengthening the blood-brain barrier, the structure that keeps harmful substances out of the brain1 • Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 €/ 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access 185,98 € per year only 3,65 € per issue Rent or buy this article Prices vary by article type from$1 • 95 Prices may be subject to local taxes which are calculated during checkout doi: https://doi • 1038/d41586-026-00515-x References Bieri, G • ArticlePubMedGoogle Scholar Bieri, G

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    • RESEARCH HIGHLIGHT How an exercise-activated enzyme helps to keep the brain young Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access 185,98 € per year only 3,65 € per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout doi: https://doi.org/10.1038/d41586-026-00515-x References Bieri, G. et al. Cell https://doi.org/10.1016/

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