• Giant viruses, like mimivirus, carry genes for translation machinery, enabling them to hijack host protein synthesis. • Researchers isolated ribosomes from infected amoebae, revealing viral proteins bound to host ribosomes. • Gene knockouts of viral initiation complexes dramatically lowered viral replication rates. • Findings blur the line between living organisms and viruses, challenging traditional definitions. • Mimivirus genes encode components of ribosomal initiation complexes, a rare viral trait. • Study highlights giant viruses as key players in understanding evolution of life.

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